Good news.  $10,000,000 can make a real difference when its focused like this.  I can’t think of a more important area to research.

Here’s an excerpt from an article about the grant from

Broad Institute Lands $10M Gift to Study Cancer Drug Resistance

May 18, 2015 –  GenomeWeb staff reporter
NEW YORK (GenomeWeb) – The Broad Institute today announced it has received a $10 million gift from the Gerstner Family Foundation to study how tumors acquire drug resistance.

The gift will support experimental cancer research at the Broad and clinical research in collaboration with Dana-Farber Cancer Institute, Harvard Cancer Center, and Memorial Sloan Kettering Cancer Center, the Broad Institute said in a statement.

Researchers at the Broad Institute will use CRISPR/Cas9 genome editing to identify the mechanisms of how tumors acquire drug resistance. “Human cancers are constantly evolving in ways that evade even the best of our innovative new drugs,” Dana-Farber Cancer Institute CEO and President Edward Benz said in a statement. “For patients to get the maximum benefit from these exciting agents, we need to devise ways to defeat this resistance.”

Scientists will also work to develop liquid biopsies and improve sequencing of circulating tumor cell genomes. At the same time, the Broad Institute and its clinical partners will launch a large sequencing study of pre-treatment tumors and drug-resistant tumors to compare the cancer genomes to find mutations that cause resistance…

Broad InstituteHere’s a link so you can read the rest.  You may need to register, but its free:

That’s a power packed team working on this.  Dana-Farber, Harvard, Sloan-Kettering.  Getting them to all work is hopeful, indeed!

Feel good and keep smiling!  Pat

Leave a Reply