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More encouraging news from ASH

December 13, 2013 Pat Killingsworth No Comments

Immunotherapies have been hot topics at the last two ASH and ASCO conferences.  That trend didn’t let up at this year’s American Society of Hematology annual meeting in New Orleans.

I just returned for six days there.  My focus was multiple myeloma; that’s my cancer, and I get paid to cover myeloma related news.  But that doesn’t mean I’m not interested in–and don’t pay attention to–promising developments in other cancers, too.

Here’s some encouraging news about continued progress using immunotherapy an AP reporter posted from ASH last weekend:

Gene therapy scores big wins against blood cancers

Dec. 8, 2013 at 4:36 PM ET

red blood cellsIn one of the biggest advances against leukemia and other blood cancers in many years, doctors are reporting unprecedented success by using gene therapy to transform patients’ blood cells into soldiers that seek and destroy cancer.

A few patients with one type of leukemia were given this one-time, experimental therapy several years ago and some remain cancer-free today. Now, at least six research groups have treated more than 120 patients with many types of blood and bone marrow cancers, with stunning results.

“It’s really exciting,” said Dr. Janis Abkowitz, blood diseases chief at the University of Washington in Seattle and president of the American Society of Hematology. “You can take a cell that belongs to a patient and engineer it to be an attack cell.”

In one study, all five adults and 19 of 22 children with acute lymphocytic leukemia, or ALL, had a complete remission, meaning no cancer could be found after treatment, although a few have relapsed since then.

These were gravely ill patients out of options. Some had tried multiple bone marrow transplants and up to 10 types of chemotherapy or other treatments.

Cancer was so advanced in 8-year-old Emily Whitehead of Philipsburg, Pa., that doctors said her major organs would fail within days. She was the first child given the gene therapy and shows no sign of cancer today, nearly two years later.

Results on other patients with myeloma, lymphoma and chronic lymphocytic leukemia, or CLL, are being reported at the hematology group’s conference in New Orleans.

Doctors say this has the potential to become the first gene therapy approved in the United States and the first for cancer worldwide. Only one gene therapy treatment is approved in Europe, for a rare metabolic disorder.

The treatment involves filtering patients’ blood to remove millions of white blood cells called T-cells, altering them in the lab to contain a gene that targets cancer, and returning them to the patient in infusions over three days.

“What we are giving essentially is a living drug” — permanently altered cells that multiply in the body into an army to fight the cancer, said Dr. David Porter, a University of Pennsylvania scientist who led one study.

Several drug and biotech companies are developing these therapies. Penn has patented its method and licensed it to Switzerland-based Novartis AG. The company is building a research center on the Penn campus in Philadelphia and plans a clinical trial next year that could lead to federal approval of the treatment as soon as 2016.

Talking with the researchers, “there is a sense of making history … a sense of doing something very unique,” said Hervé Hoppenot, president of Novartis Oncology, the division leading the work.

Lee Greenberger, chief scientific officer of the Leukemia and Lymphoma Society, agreed.

“From our vantage point, this looks like a major advance,” he said. “We are seeing powerful responses … and time will tell how enduring these remissions turn out to be.”

The group has given $15 million to various researchers testing this approach. Nearly 49,000 new cases of leukemia, 70,000 cases of non-Hodgkin lymphoma and 22,000 cases of myeloma are expected to be diagnosed in the United States in 2013.

Many patients are successfully treated with chemotherapy or bone marrow or stem cell transplants, but transplants are risky and donors can’t always be found. So far, gene therapy has been tried on people who were in danger of dying because other treatments failed.

The gene therapy must be made individually for each patient, and lab costs now are about $25,000, without a profit margin. That’s still less than many drugs to treat these diseases and far less than a transplant.

The treatment can cause severe flu-like symptoms and other side effects, but these have been reversible and temporary, doctors say.

Penn doctors have treated the most cases so far — 59. Of the first 14 patients with CLL, four had complete remissions, four had partial ones and the rest did not respond. However, some partial responders continue to see their cancer shrink a year after treatment.

“That’s very unique to this kind of therapy” and gives hope the treatment may still purge the cancer, said Porter. Another 18 CLL patients were treated and half have responded so far.

There’s more!  Read the second half of the article by clicking on the link below:

http://www.nbcnews.com/health/gene-therapy-scores-big-wins-against-blood-cancers-2D11708740

More news from ASH this weekend.  Feel good and keep smiling!  Pat

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