Happy Memorial Day weekend to all of my American readers!  I have been saving a number of cancer related news items to share with you for a number of weeks now.  Here are two completely different and unrelated stories that I wanted to share.

First, here’s an email I received from cancer caregiver and activist, Susan Vento:

Hello Pat,

My name is Susan Vento, and I am writing to you about a cause that is very close to my heart. On October 10th 2000 my husband, Bruce Vento, passed away. He was serving as a congressman for the state of Minnesota when he was diagnosed with pleural mesothelioma, a very rare cancer that is caused by asbestos exposure and kills 90-95% of its victims.

Since you and I have both been affected by cancer in some capacity, and due to your influence and experience in the online cancer community, I am reaching out to you asking for your help. I am a spokesperson for the Asbestos Cancer Victims’ Rights Campaign (www.cancervictimsrights.org). The ACVRC is a national campaign dedicated to protecting the rights of cancer victims and their loved ones. Our goal is to gain as many signatures to our petition as possible to show public support.

I hope that you will join our fight to defeat any and all unfair legislation that burdens cancer victims by sharing the campaign’s mission on your blog. If I could provide you with some content to post so that your blog’s viewers can also join the campaign, please let me know!

Thanks for your time and consideration,

Susan

I’m sure that Susan–and those she represents, would appreciate your signing their petition.

Next, prepare to be amazed as you read about radioactive nanoparticles that scientists at the University of Missouri are using to target and destroy lymphoma cancer cells:

MU Researchers Develop Radioactive Nanoparticles that Target Cancer Cells

This is an early step toward developing therapies for metastasized cancers, MU scientist says

Story Contact: Nathan Hurst, [email protected], 573-882-6217

For photos available with this release, please click here.

COLUMBIA, Mo. — Cancers of all types become most deadly when they metastasize and spread tumors throughout the body. Once cancer has reached this stage, it becomes very difficult for doctors to locate and treat the numerous tumors that can develop. Now, researchers at the University of Missouri have found a way to create radioactive nanoparticles that target lymphoma tumor cells wherever they may be in the body. Michael Lewis, an associate professor of oncology in the MU College of Veterinary Medicine, says being able to target secondary tumors is vital to successfully treating patients with progressive cancers.

“Depending on the type of cancer, primary tumors usually are not the cause of death for cancer patients,” Lewis said. “If a cancer metastasizes, or spreads creating hard-to-find tumors, it often becomes fatal. Having a way to identify and shrink these secondary tumors is of utmost importance when fighting to save people with these diseases.”

In an effort to find a way to locate and kill secondary tumors, Lewis, in collaboration with J. David Robertson, director of research at the MU Research Reactor and professor of chemistry in the College of Arts and Science, have successfully created nanoparticles made of a radioactive form of the element lutetium. The MU scientists then covered the lutetium nanoparticles with gold shells and attached targeting agents.

In previous research, Lewis has already proven the effectiveness of similar targeting agents in mice and dogs suffering from tumors. In that research, the targeting agents were attached to single radioactive atoms that were introduced into the bodies of animals with cancer. The targeting agents were able to seek out the tumors existing within the animals, which were then revealed through radio-imaging of those animals.

In their current research, the MU scientists have shown the targeting agents can deliver the new radioactive lutetium nanoparticles to lymphoma tumor cells without attaching to and damaging healthy cells in the process. Robertson says this is an important step toward developing therapies for lymphoma and other advanced-stage cancers.

“The ability to deliver multiple radioactive atoms to individual cancer cells should greatly increase our ability to selectively kill these cells,” Robertson said. “We are very optimistic about the synergy of combining the targeting strategy developed in Dr. Lewis’s lab with our work on new radioactive nanoparticles.”

Lewis has been invited to present his research at the City of Hope National Medical Center this June in Duarte, Calif.

This study is an example of the collaborative research taking place in the One Health, One Medicine area of Mizzou Advantage. The early-stage results of this research are promising. If additional studies, including animal studies, are successful within the next few years, the researchers will request permission from the federal government to begin human drug development. After this status has been granted, Lewis and Robertson may conduct human clinical trials with the hope of developing new treatments.

Lewis also is a principal investigator in the Research Service at the Harry S. Truman Memorial Veterans’ Hospital. This research was supported by awards from the National Cancer Institute and the Department of Veterans Affairs as well as resources made available by Department of Veterans Affairs through use of facilities at the Harry S. Truman Memorial Veterans’ Hospital in Columbia, Mo.

Sometimes don’t you get the feeling that technology is getting ahead of our ability to understand and harness it?

Feel good and keep smiling!  Pat

2 thoughts on “Mesothelioma, anti-cancer nanoparticles and the power of the human spirit…

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