Here is the beginning of a fascinating article about genetic risk among women for breast cancer we discovered on MedPage Today:

BRCA Boosts Risk of Contralateral Cancer
By Charles Bankhead, Staff Writer, MedPage Today
Published: April 05, 2010
Reviewed by Dori F. Zaleznik, MD; Associate Clinical Professor of Medicine, Harvard Medical School, Boston and
Dorothy Caputo, MA, RN, BC-ADM, CDE, Nurse Planner

Women who have breast cancer related to BRCA mutations have a four-fold greater risk of contralateral breast cancer compared with patients who have sporadic breast cancer, data from a large case-control study showed.

The risk was higher for BRCA1 mutation carriers, and the risk increased with younger age at first diagnosis, according to an article published online in the Journal of Clinical Oncology.

“A woman with breast cancer before age 55 who carried a BRCA1 or BRCA2 mutation was estimated to have a 20% or 15% probability, respectively, of developing contralateral breast cancer within 10 years,” Kathleen E. Malone, PhD, of Fred Hutchinson Cancer Research Center in Seattle, and colleagues reported.

“Risks were substantially greater for women diagnosed with their first cancer at younger ages and, as in other studies, mutations were more common in patients with younger age at diagnosis,” they wrote.

“These findings have important clinical implications in terms of the potential value of BRCA1/BRCA2 testing in patients with early-onset breast cancer, as well as therapeutic, preventive, and surveillance considerations for patients found to carry a mutation,” the authors concluded.

Mutations in the BRCA1/2 breast cancer susceptibility genes confer a lifetime breast cancer risk of 36% to 84%.

Read on by going to: BRCA Boosts Risk of Contralateral Cancer.
Feel good and keep smiling! Pat & Pattie

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